TRIM40 and inflammatory bowel disease: Notably, the transcriptome landscape of TRIM40-overexpressing HT-29 cells showed substantial changes in genes that are signatures of IBD, including cytoskeleton-related and interferon (IFN)-stimulating genes (ISGs), which was also confirmed by quantitative PCR (qPCR) assays (Fig. 1g, h, Supplementary Fig. 1c, and Supplementary Data 1).