Disulfiram [25], a drug that is used to treat alcohol addiction, and BAY 11-7082 [33], a previously identified irreversible inhibitor of the NF-κB pathway, potently inhibited GSDMD pore formation and inflammasome-mediated pyroptosis and IL-1β secretion in liposomes by covalently modifying Cys191/Cys192, which is conserved in GSDMD. The gene discussed is IL1B; the disease is Addictive alcohol use.