It has been demonstrated that the presence of pyroptosis markers in brain tissue after stroke, such as NOD-like receptor family pyrin domain containing 3 (NLRP3), caspase-1/11 and gasdermin D (GSDMD), causes an inflammatory response and exacerbates damage to brain tissue and that inhibiting pyroptosis has a neuroprotective effect [10, 11]. Here, GSDMD is linked to Stroke.