In an in vitro AMD model, Aβ1-40 aggregation in drusen not only activated the NLRP3 inflammasome in ARPE-19, but also upregulated the expressions of GSDMD-N, IL-1β, and IL-18, suggesting that Aβ-mediated classical pyroptosis injures RPE cells [78]. The gene discussed is IL18; the disease is age-related macular degeneration.