Significant reduction of collagen mRNA and Collagen I protein by Vgll3 knockdown was observed in cardiac myofibroblasts, as well as in liver myofibroblasts isolated from NASH model mice (Fig. 3g, h), and from mice with CCl4-induced liver fibrosis (Supplementary Fig. 5b), or CCD-18Co cells (Fig. 3i, Supplementary Fig. 5c). Here, VGLL3 is linked to Hepatic fibrosis.