TWIST1 and neoplasm: The tumor immune microenvironment can also affect EMT programs, since FN1 and CRB3 marker genes are IFN-regulated ones (IRG = IFN-regulated gene); furthermore, some of the TFs of EMT are all regulated by IFN: SNAI1, TWIST1/2, ZEB1/2, SIX1, SOX4, and TCF4, according to the Interferome database [25] (Supplementary Table 1).