In colorectal cancer (CRC) tissues, RPPH1 induces epithelial-mesenchymal transition (EMT) by preventing ubiquitination of β-tubulin TUBB3 and promotes local macrophage polarization through exosomal transfer of CRC-expressed RPPH1 (Liang et al., 2019). The gene discussed is RPPH1; the disease is colorectal carcinoma.