7SK and cancer: As a generally repressive regulator of transcription, both 7SK and the 7SK-snRNP have been described as putative tumor suppressors: loss of LARP7 and the 7SK snRNP leads to upregulation of epithelial-mesenchymal transition (EMT) associated genes and increased invasion and metastasis in breast cancer (Ji et al., 2014), and exogenous over-expression of 7SK inhibits cell proliferation in cancer cell lines (Keramati et al., 2015).