TNF and Hypercholesterolemia: In a study of the systemic anti-inflammatory and endothelial protective effects of ezetimibe (10 mg/day; 90 days), atorvastatin (40 mg/day; 90 days) and atorvastatin-ezetimibe (in the same doses) in patients with hypercholesterolemia, Krysiak et al. (2012) report that atorvastatin and combined therapy had beneficial effects on high-sensitivity C-reactive protein (hsCRP), ICAM-1, tumor necrosis factor α (TNFα), interferon γ (IFNγ), and IL-2 serum concentrations, while ezetimibe monotherapy had no effect [47, 48].