Specifically, the index SNV rs20551 at 22q13.2 locus (PLACO P = 5.07 × 10−11 for IBS-schizophrenia) was a significant eQTL for EP300 (OMIM 602700) encoding p300 protein, which plays an important role in cell proliferation and differentiation. This evidence concerns the gene EP300 and irritable bowel syndrome.