Overall, pleiotropic variants between gastrointestinal tract diseases and psychiatric disorders were extensively distributed, with several loci especially highlighted between certain trait pairs, such as 1q32.1 (INAVA), 19q13.33 (FUT2), 11q23.2 (NCAM1), and 1p32.3 (LRP8). This evidence concerns the gene NCAM1 and psychiatric disorder.