FASN and cancer: In this scenario, the overexpression/activity of the key anabolic multienzyme fatty acid synthase (FASN), which catalyzes the last step in the de novo biosynthesis of fatty acids (FAs), represents one of the most frequent alterations that provide cancer cells with fuel to sustain the exacerbated energetic and biosynthetic demands and signaling that are essential for their proliferation, survival and invasion [20].