GPT and asthenia: In the Keynote-524 study, grade 3 TEAEs were hypertension (18%), increased AST levels (14%), increased lipase levels (11%), diarrhea (7%), increased blood bilirubin levels (6% at level 3 and 2% at level 4), fatigue (6%), asthenia (6%), increased ALT levels (6%), decreased weight (5%) and proteinuria (5%) [15].