GPT and Hyperglycemia: CR = 1 pt (TNBC), PR = 7 pts, ORR = 23%, CBR: 43%. mPFS = 5.2 months, mOS = 20.6 months, TTF = 5.84 months and 1.8 months for TNBC. Adverse events included fatigue (G1 = 75% and G2 = 10%), neuropathy (G1 = 65% and G2 = 2.5%) and diarrhea (G1 = 50% and G2 = 15%). G 3/4 events included neutropenia and anemia (10% each), Lymphopenia (20%), hyperphosphatemia and hyperglycemia (5% each), Thrombocytopenia, Hypokalemia and ALT elevation (2.5% each)