The main findings in the present study are (i) a reduced frequency and (ii) altered phenotype of CD24hiCD27+ putative Breg cells in patients with GPA/PR3-ANCA+ vasculitis compared with HC, and (iii) that induced Breg cells during remission could regulate T-cell proliferation and production of certain cytokines but failed to regulate IFN-γ and TNF production. This evidence concerns the gene TNF and granulomatosis with polyangiitis.