GBA1 and Parkinson disease: As GCase deficiency results in downstream abnormalities in other lipids including phosphatidic acid, phosphatidylethanolamine, plasmal-ogenphosphatidylethanolamine (PEp), acyl phosphatidylglycerol, lactosylceramide and gangliosides (63,71–73), additional studies are required to delineate their contribution to GBA1 dysfunction and pathogenesis in PD and Lewy Body Dementia (LBD) syndromes (74–76).