Indeed, AIF and its associated nuclease, macrophage migration inhibitory factor (MIF) (rechristened as PARP-1-dependent AIF-associated nuclease or PAAN), are key players in “parthanatos” (Kam et al., 2018; Wang et al., 2016), a regulated necrosis implicated in neurodegenerative disease. The gene discussed is MIF; the disease is neurodegenerative disease.