The lower rate of PTEN deletion among BL patients may be, in large part, due to the established lower frequency of ERG gene rearrangement in this population (11, 22–24), since PTEN deletion is highly enriched among tumors with ERG rearrangement (45, 46) and ERG fusions precede PTEN loss in the majority of cases (47, 48). Here, PTEN is linked to Burkitt lymphoma.