Comparing the signaling markers either upregulated (red circles in the table) or downregulated (blue circles in the table) among MM stages (Figure 6C), we found 4 markers (CD200, sXBP-1, MMSET, and Bcl-6) overexpressed only in SMM and 7 markers (IRF-4, Nestin, CD319, Sox2, RARa2, CD289, and c-Myc) modulated in NDMM, whereas the modulation of 5 molecules (CD28, MMSET, Nanog, Nestin, and CD289) was noted among MGUS, SMM, and NDMM in different PC clusters (Figure 6C). Here, CD28 is linked to Miyoshi myopathy.