Significant modulation of CD117, CD25, Bcl-2, fibroblast growth factor receptor 3 (FGFR3), Bcl-6, retinoic acid receptor α2 (RARα2), CD269, Nanog, KLF-4, CD81, and IRF-4 expression was defined in both hsc and pre-pro-B cells of MM, as well as differences in expression of CD200, CD362 (hsc), octamer-binding transcription factor 3/4 (Oct3/4), CD289, and sXBP-1 (pre-pro-B). The gene discussed is IRF4; the disease is Miyoshi myopathy.