Similar to earlier B maturation stages, the summary circle and Venn diagrams show mostly upregulated B cell signaling regulators (including MMSET, MYD88, c-Myc, CXCR4, and Notch-1), stem cell marker KLF-4, ABC transporter CD243, and PC aberrant marker CD47 in all stages of MM, with upregulated sXBP-1 only in SMM (Figure 4C). Here, NSD2 is linked to Miyoshi myopathy.