Summary circle and Venn diagrams show upregulated B cell signaling regulators (including MYD88, MMSET, c-Myc, Notch-1, CXCR4, IRF-4, Bcl-6, and Bcl-2), ATP-binding cassette (ABC) transporter CD243, and PC aberrant markers (such as CD47, CD52, CD269, CD117, and CD25) in B cell precursors/progenitors in all MM stages (Figure 2C). Here, MYD88 is linked to Miyoshi myopathy.