Our results show that the expression of β‐catenin, c‐myc, CyclinD1, P21, HK2 and PKM2 were elevated in ASPP2‐depleted HCC‐LM3 and Hep‐G2 cells (Figure 3A,B), but was decreased in ASPP2‐overexpressed Huh‐7 cells (Figure 3C). The gene discussed is HK2; the disease is hepatocellular carcinoma.