PFKFB3 and hepatocellular carcinoma: The mRNA level of key glycolytic regulators like hexokinase 2 (HK2), 6‐phosphofructo‐ 2‐kinase /fructose‐2, 6‐bisphosphatase 3 (PFKFB3) and pyruvate kinase M2 (PKM2) were notably elevated in ASPP2‐depleted HCC‐LM3, HepG2 and Hep3B cells, whereas these were decreased in ASPP2‐overexpressed Huh‐7 cells (Figure 2A).