We have also demonstrated that the two non-coding RNAs (ncRNAs) hydatidiform mole-associated and imprinted (Hymai) and plagl1 intronic transcripts (Plagl1it), which reside in the Plagl1 genomic locus, may also participate in the regulation of the Plagl1 promoters. The gene discussed is PLAGL1; the disease is hydatidiform mole.