Upon endoplasmic reticulum stress, amplified FGF19 promotes tumor cell proliferation through activating fibroblast growth factor (FGF) receptor 4 (FGFR4)-glycogen synthase kinase-3beta (GSK3β)-nuclear factor erythroid-2-related factor-2 (Nrf2) signaling in hepatocellular carcinoma (Teng et al., 2017). This evidence concerns the gene GSK3B and hepatocellular carcinoma.