TARDBP and amyotrophic lateral sclerosis: Western blot analysis showed that TDP-43i induced a significant reduction of TDP-43 abundance in control cells (CTRL1 P < 0.0001; CTRL2 P < 0.0001) and ALS fibroblasts (ALS1A P = 0.0007; ALS2A P = 0.0006), while transfection with allele-specific siM10 did not change the protein amount in controls but significantly reduced TDP-43 levels in ALS patient cells (ALS1A P = 0.0032; ALS2A P = 0.0114; Fig. 3A and B).