To test whether allele-specific siRNA could decrease endogenous TDP-43G376D levels in cells derived from patients, we transfected dermal fibroblasts previously isolated from ALS patients carrying the p.G376D TDP-43 mutation (ALS fibroblasts), and healthy individuals without the mutation (CTRL = control patients) with siM10, TDP-43i and control RNA. The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.