TARDBP and amyotrophic lateral sclerosis: We wondered if M10 could revert this phenotype; therefore, we treated fibroblasts with control RNA and M10 and we observed a reduction in the number of ALS cells showing aggregates following M10 treatment, while the cytoplasmic TDP-43 deposits were still visible in the cells of the same patient treated with control RNA (Fig. 4C and D).