WDR45 and neurodegeneration with brain iron accumulation 5: Static encephalopathy of childhood with neurodegeneration in adulthood (SENDA)/β-propeller protein-associated neurodegeneration (BPAN) (OMIM #300894) is a neurodegenerative disease caused by a de novo mutation of WD repeat domain 45 (WDR45) located on Xp 11.23.