Compared with NT or CTRL-IgG treated cells, NMO-IgG increased Cx43 spot size in a patient-dependent manner (Fig. 2B, NT = 0.218 ± 0.035; CTRL-IgG = 0.295 ± 0.069; NMO1-IgG = 0.233 ± 0.029; NMO2-IgG = 0.348 ± 0.042; NMO3-IgG = 0.346 ± 0.067; NMO4-IgG = 0.325 ± 0.053; NMO5-IgG = 0.303 ± 0.039; NMO6-IgG = 0.283 ± 0.031; NMO7-IgG = 0.282 ± 0.038 μm2). This evidence concerns the gene GJA1 and neuromyelitis optica.