PTH and hyperparathyroidism: As in other rodent studies and human hyperparathyroidism, infusion of PTH and abaloparatide led to a decrease in cortical thickness and an abnormal remodeling of trabecular bone.(38, 53, 54, 55, 56) With both treatments, trabecular bone in this catabolic mouse model shows no major changes in bone volume but an increase in trabecular separation (which reflects increased osteoclast activity) and decreased trabecular thickness.