Importantly, TLR4 stimulation activated perivascular macrophages to induce endothelial cell‐mediated production of a pro‐metastatic vascular niche during breast cancer colonisation in the lung,19 suggesting that paclitaxel might be useful for the induction of anti‐tumour immune responses against cancers, but it also induces angiogenesis to promote cancer development. This evidence concerns the gene TLR4 and breast carcinoma.