Previous case reports as well as a randomised controlled clinical trial showed a significant improvement of reepitalisation in patients with TEN after Etanercept application in comparison with traditional therapy with corticosteroids (Wang et al, 2018) TNF‐alpha inhibition reduces proinflammatory cytokines and the secretion of granulysin.15, 16. The gene discussed is GNLY; the disease is toxic epidermal necrolysis.