Our database also includes recent cryo-EM structures that reveal the molecular structures of the five globular A and C domains in FV and FVa for the first time (PDB IDs: 7KVE, 7KXY).21In addition, a full-length protein model for FV that includes the disordered B domain structure was predicted by the AlphaFold neural networking and machine learning method.22The assembly of these datasets provides insights on the disease mechanisms for FV deficiency. The gene discussed is F5; the disease is hyperinsulinemic hypoglycemia, familial, 4.