This study shows the effect of DOACs (thrombin inhibitor: dabigatran etexilate [DABE] and factor Xa inhibitor: rivaroxaban [RVX] and edoxaban [EDX]) on tumor growth in mice inoculated with mouse-derived colorectal cancer Colon26 cells.18Next, based on the finding that EDX significantly inhibited tumor growth in Colon26-inoculated mice, the basic mechanism of tumor growth inhibition by EDX in mice inoculated with Colon26 cells was analyzed. Here, F10 is linked to neoplasm.