The PAR1 expression level in the tumor tissues from the EDX-treated group did not change significantly compared with that from the water-treated group, but the PAR2 expression level in the tumor tissues from the EDX-treated group was significantly reduced compared with that from the water-treated group (p<0.01).Fig. 4Ashows immunofluorescence data for PAR1 and PAR2 expression levels in normal or tumor tissues. This evidence concerns the gene F2RL1 and neoplasm.