TP53 and neoplasm: To investigate the possible mechanisms of EDX-associated apoptosis, the levels of p53 protein, which has an antitumor effect by inducing apoptosis in the tumor,23were evaluated.Fig. 5Cshows the expression levels of p53 protein in normal thigh tissues of UTR mice and tumor tissues of water-treated or EDX-treated group of Colon26-inoculated mice.