Because intratumoral angiogenesis is closely related to tumor tissue growth, and PAR2 induces angiogenesis and promotes tumor growth,35we analyzed the effect of EDX on the expression of VEGF-A and its receptor VEGFR-1, which are primarily involved in angiogenesis,36and found that EDX treatment did not affect the expression levels of both factors, suggesting that the factor Xa-PAR2 pathway is not involved in tumor angiogenesis. This evidence concerns the gene TNXA and neoplasm.