CRP and diabetes mellitus: Diabetes, a systemic disorder with significant periodontal disease manifestation, is also viewed as an inflammatory condition and its development is preceded by a low-grade systemic inflammation [2] with elevated plasma concentrations of pro-inflammatory markers such as C-reactive proteins (CRP), cytokines (interleukin-1β, interleukin-6, tumor necrosis factor-α (alpha), and prostanoids (prostaglandin E2) [3].