BRAF and cancer: The B-Raf protooncogene variant BRAF (V600E) upregulates MafG, which heterodimerizes with Bach1 and recruits both chromodomain helicase DNA-binding protein 8 (CHD8, a chromatin remodeling factor) and the DNA methyltransferase DNMT3B, leading to transcriptional silencing of tumor suppressor genes and cancer proliferation [124].