EGFR and non-small cell lung carcinoma: Osimertinib, a third-generation EGFR-TKI targeting NSCLC with EGFR T790M mutations, is now a first-line treatment for EGFR mutation-positive advanced NSCLC patients, and it has also been shown to demonstrate higher effectiveness for BM than the older EGFR-TKIs including gefitinib or erlotinib [9].