In this study, we examined the PET images of participants from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) cohort to investigate how baseline Aβ and tau levels affect longitudinal tau propagation over time in MTL, inferior temporal, and middle temporal cortices, as well as how age, sex, APOE-ε4, and KL-VShet modulate these relations. The gene discussed is APOE; the disease is early-onset autosomal dominant Alzheimer disease.