Previous post-mortem [13] and neuroimaging [14, 15] studies have shown that tau tangles typically spread systematically across the medial temporal lobe (MTL, Braak stages I–III), encompassing hippocampus, transentorhinal, and parahippocampal cortices [16], followed by their expansion to the association cortices (Braak stages III–IV), and eventually reaching the isocortical regions (Braak stages V–VI) in amnestic/typical AD [17, 18]. This evidence concerns the gene MAPT and Alzheimer disease.