DOCK1 and cancer: In addition, 1-[2-(3′-(trifluoromethyl)-(1,1′-biphenyl)-4-yl)-2-oxoethyl]-5-pyrrolidinylsulfonyl-2 (1H)-pyridone (TBOPP), a selective inhibitor of Dedicator of cytokinesis 1(DOCK1), inhibits macropinocytosis and invasion in cancer cells and also suppresses cancer growth and metastasis in vivo [102].