Additionally, eATP acting at the P2X7R has been implicated in the induction of EMT, promotion of MMP and cathepsin secretion, and the increased motility and invasive capacity in human melanoma, breast, and prostate cancer cells via activation of Ca2+-activated SK3 potassium channels or the PI3K/AKT pathway [64–66]. The gene discussed is AKT1; the disease is prostate cancer.