Additionally, eATP acting at the P2X7R has been implicated in the induction of EMT, promotion of MMP and cathepsin secretion, and the increased motility and invasive capacity in human melanoma, breast, and prostate cancer cells via activation of Ca2+-activated SK3 potassium channels or the PI3K/AKT pathway [64–66]. This evidence concerns the gene AKT1 and Familial prostate cancer.