H2O2, an upstream trigger of GPX8 upregulation in brain cells [41], enhanced GPX8 expression in ccRCC cells concentration dependently (Fig. 8H); meanwhile, it also gradually increased phenotypic lipid accumulation in GPX8-WT cells, but not in GPX8-KO cells (Fig. 8I). The gene discussed is GPX8; the disease is nonpapillary renal cell carcinoma.