When we analyzed the ccRCC single-cell RNA sequencing data [25], NNMT expression was clearly higher in tumor cells than in other cell types but similar between the WT- and MT-VHL tumor cells (Figs. 8A, B, and S8A) (Unfortunately, GPX8 expression could not be analyzed, due to non-reliable detection in this particular dataset). This evidence concerns the gene GPX8 and nonpapillary renal cell carcinoma.