In addition, immune checkpoint inhibitor expression was significantly higher in HCC with high risk, particularly CD274, CD276, CD4, CTLA4, CXCR4, IL1A, LAG3, TGFB1, TNFRSF4, TNFRSF9 and TNFSF4 (Fig. 6B). Here, CD276 is linked to hepatocellular carcinoma.