In addition, immune checkpoint inhibitor expression was significantly higher in HCC with high risk, particularly CD274, CD276, CD4, CTLA4, CXCR4, IL1A, LAG3, TGFB1, TNFRSF4, TNFRSF9 and TNFSF4 (Fig. 6B). The gene discussed is IL1A; the disease is hepatocellular carcinoma.