In addition, immune checkpoint inhibitor expression was significantly higher in HCC with high risk, particularly CD274, CD276, CD4, CTLA4, CXCR4, IL1A, LAG3, TGFB1, TNFRSF4, TNFRSF9 and TNFSF4 (Fig. 6B). This evidence concerns the gene TNFRSF9 and hepatocellular carcinoma.