SP1 and acute myeloid leukemia: For instance, the m6A modification is associated with the translation of mRNAs in acute myeloid leukemia (AML) cells, and the m6A ‘writer’ METTL3 can be recruited by the TF CEBPZ to specific genomic loci promoters, which leads to m6A on a few oncogene mRNAs especially SP1 and promotes translation as well as regulates c-MYC expression and AML cell growth [80].