PURB and breast cancer: At the Tensin1 promoter region, the chromatin-associated lncRNA MaTAR25 can recruit and specifically interact with purine rich element binding protein B (PURB), a transcriptional coactivator and sequence-specific DNA-binding protein that also has RNA-binding ability, which upregulates the focal adhesion complex component Tensin1 linking the intracellular cytoskeleton and extracellular matrix, ultimately resulting in breast cancer cell proliferation, invasion and migration [133].