CircMRPS35 can specifically bind to the promoters of the FOXO1 and FOXO3a genes and be a scaffold to recruit histone acetyltransferase Lysine Acetyltransferase 7 (KAT7) depositing H4K5ac and activating FOXO1 and FOXO3a transcription, which leads to upregulation of p21 and p27 and downregulation of Twist Family BHLH Transcription Factor 1 (Twist1) and E-cadherin as well as subsequent inhibition of gastric cancer proliferation and invasion [142]. The gene discussed is TWIST1; the disease is gastric cancer.