NR1H3 and glioblastoma: On the other hand, m6A readers mediate RNA decay, which is associated with tumorigenesis, YTHDF2 is observed to be overexpression in glioblastoma cells and plays an important role in cholesterol metabolism-associated liver X receptor a (LXRa) and HIVEP zinc finger 2 (HIVEP2) mRNA decay in a m6A-dependent manner, which finally causes cholesterol dysregulation and promotes the glioblastoma cell proliferation, invasion and tumorigenesis [125].