Likewise, Rho GTPase activating protein 5 (ARHGAP5) antisense transcript lncRNA ARHGAP5-AS1 can not only promote ARHGAP5 transcription by interacting with chromatin but also recruit METTL3 to ARHGAP5 mRNA, elevating the m6A modification level and stability of ARHGAP5 mRNA in the cytoplasm, which ultimately increases the chemoresistance of gastric cancer (GC) [127]. This evidence concerns the gene METTL3 and gastric cancer.