Correspondingly, the depletion of the m6A methyltransferase METTL3 in macrophages can decrease the YTHDF1-mediated translation of Sprouty Related EVH1 Domain Containing 2 (SPRED2), impairing the inhibition of ERK by SPRED2, which eventually leads the activation of NF-κB and Signal Transducer and Activator of Transcription 3 (STAT3) as well as facilitates tumor growth and metastasis [124]. This evidence concerns the gene SPRED2 and neoplasm.