For example, the oncogenic circRNA circIPO11 can recruit topoisomerase 1 (TOP1) to the GLI family zinc finger 1 (GLI1) promoter and then activate its transcription, which promotes self-renewal of liver cancer stem cells (CSCs) and promotes the progression of hepatocellular carcinoma (HCC) via Hedgehog signaling [141]. The gene discussed is GLIS1; the disease is hepatocellular carcinoma.