For instance, lncRNA FOXD2-AS1 can recruit PRC2 submit Enhancer of zeste homolog 2 (EZH2) to the Cyclin Dependent Kinase Inhibitor 1B (CDKN1B) promoter region and deposit H3K27me3, which silences CDKN1B gene transcription, leading to the downregulation of CDKN1B-coded cyclin-dependent kinase inhibitor p27 and proliferation of hepatocellular carcinoma [138]. This evidence concerns the gene EZH2 and hepatocellular carcinoma.