In anaplastic large cell lymphoma (ALCL), the STAT3-regulated caRNA BlackMamba has the capability to bind and recruit the chromatin remodeling protein lymphoid-specific helicase (LSH/HELLS) to the promoter region of genes related to tumor migration, cytoskeleton formation and inflammation, which increases associated protein expression and maintains the lymphoma kinase-negative (ALK-) ALCL neoplastic phenotype and cell growth [137]. The gene discussed is HELLS; the disease is anaplastic large cell lymphoma.