The latest research found that lncRNA LINC00839 acts as an RNA scaffold to recruit transcriptional activator RuvB-like AAA ATPase 1/Lysine Acetyltransferase 5 (Ruvb1/KAT5) complexes to the Nuclear Respiratory Factor 1 (NRF1) promoter region and increases H4K5ac and H4K8ac levels at the promoter, which increases NRF1 expression and finally promotes colorectal cancer (CRC) cell OXPHOS and CRC progression [136]. The gene discussed is NRF1; the disease is colorectal cancer.