Most recent research illustrates that circNCOR1 can recruit hnRNPL to the SMAD7 promoter and directly insert into the DNA double strand to form a DNA–RNA triplex, which increases histone acetyltransferase p300-dependent H3K9ac and transcription of SMAD7, finally leading to SMAD7-mediated suppression of the TGFβ/SMAD signaling pathway and inhibition of bladder cancer (BC) cell growth as well as lymph node metastasis. The gene discussed is SMAD7; the disease is urinary bladder carcinoma.