Furthermore, survival analysis, nuclear-cytoplasmic localization study, and correlation analysis of RNAs from triple regulatory networks showed a critical ceRNA network (HELLPAR-hsa-let-7i-5p-RRM2).Finally, the diagnostic and prognostic values of RRM2 in gliomas were determined using expression analysis, survival analysis, and cox regression analysis. The gene discussed is RRM2; the disease is glioma.