GREM1 and central nervous system cancer: During the disease process of gliomas, lncRNA LINC01057 can promote mesenchymal differentiation by activating NF-kB signaling in glioblastoma, lncRNA BCYRN1 can prevent gliomas carcinogenesis by competitively interacting with miR-619-5p to modulate CUEDC2 expression, lncRNA PVT1 can enhance gliomas tumorigenesis and progression by modulating the MiR-128-3p/GREM1 axis and the BMP signaling pathway and the like [29–31].