In conclusion, this study provides multi-layered and multifaceted evidence for the importance of HMMR in gliomas and establishes a HMMR related ceRNA (HEELPAR-hsa-let-7i-5p-RRM2) overexpressed network of gliomas, which is better for understanding the link among lncRNA-miRNA-mRNA. Here, RRM2 is linked to central nervous system cancer.