E2F3 and brain ischemia: miR-874-3p reportedly inhibits tumor growth or metastasis by regulating signal transducer and activator of transcription 3, cyclin-dependent kinase 9, and E2F transcription factor 3; reduces brain ischemia by regulating BCL-2-modifying factor in reperfusion injury; and reduces apoptosis and inflammation in alveolar epithelial cells by targeting early growth response 3/nuclear factor-kappa B [51–53].