Transcription factors linked specifically with genes identified in the male-specific broad MDD GWAS were related to tissue and neuron differentiation as well as epigenetic processes (e.g., E2F1, Esrrb, NRSF, ZFX, ZNF423), which is consistent with the results of the gene enrichment analyses (see Fig. 2) that underscore the potential role for chromatin remodeling factors in males. The gene discussed is REST; the disease is major depressive disorder.