Transcription factors uniquely associated with genes identified in the female broad MDD GWAS were linked to oxidative stress, apoptosis and type II diabetes (e.g., HNF3-beta, MafA, p63, RelA, VDR), which aligns with the genetic correlation of the female-specific GWAS with cardio-metabolic conditions (see Table 1). Here, VDR is linked to type 2 diabetes mellitus.