GPT and hypertensive disorder: In the combination group, AEs of any grade (>10%) were elevated aspartate aminotransferase (47.8%), abdominal pain (39.0%), elevated alanine transaminase (36.8%), pyrexia (25.4%), elevated bilirubin (22.4%), hypertension (13.6%), hand-foot skin reaction (13.2%), and proteinuria (10.5%) (Supplementary Table 3).