BTG3 and systemic lupus erythematosus: Lastly, we constructed polygenic risk scores (PRS) and validated the models in two independent biobanks: Michigan Genomic Initiative (MGI)24 and Vanderbilt University Biobank (BioVU) and investigated the utility of PRS to improve the diagnosis of SLE when used in conjunction with clinical lab tests, e.g., anti-nuclear antibody (ANA) and anti-double strand DNA (anti-dsDNA).