Although no significant change observed in p53 and p21, co-transfection of siRRP15 and siLZTS2 effectively reversed RRP15 KD-induced β-catenin nuclear export and down-regulation (Figs. 7D–F and S13A), as well as considerably rescued RRP15 KD-mediated inhibition of proliferative and metastatic activity in CRC cells (Figs. 7G–J and S13B–E). The gene discussed is RRP15; the disease is colorectal carcinoma.