In addition, p53, ACOX1 and KAT2B proteins were significantly decreased in CRC samples relative to control adjacent normal colonic tissue (Figs. 7a and S7a), which is consistent with the data from TCGA, GEO and Clinical Proteomic Tumor Analysis Consortium (CPTAC) database (Figs. 7b, S7b and S7c). Here, ACOX1 is linked to colorectal carcinoma.