COX-2 is known to be generally absent in most normal cells but is highly enriched in many malignant cells like colorectal, lung, breast and prostate cancers; and PGE2, the major bioactive metabolite of COX genes, can promote the proliferation of cancer cells, enhance their stemness and protect them from apoptosis [24]. The gene discussed is PTGS2; the disease is Familial prostate cancer.