MAP2K4 and neoplasm: Multiple tumor suppressor genes like PHF23, EIF5A, KCTD11, MAP2K4 and ALOX15B, have been reported to promote tumorigenesis when lost, indicating that gene expression regulation, signal transduction, arachidonate lipoxygenase and other cellular pathways are altered with the loss of chromosome 17p [2, 5, 6, 8].