TP53 and lymphoma: As Fig. 1B shown, two AA derivatives oxygenated by the cyclooxygenase pathway, prostaglandin E2 (PGE2) and thromboxane B2 (TXB2), were increased in 11B3-deleted lymphoma cells, while multiple metabolites produced from arachidonate lipoxygenases, including hydroxyeicosatetraenoates (HETEs) were reduced in 11B3-deleted cells compared to Trp53 loss only lymphoma cells.