ALOX15 and neoplasm: Besides ALOX15B, there are four other arachidonate lipoxygenases locating on chromosome 17p, including ALOX12, ALOX12B, ALOX15 and ALOXE3. Among them, Alox12 was reported to be required for the tumor suppression functions of p53 in an Eμ-Myc mouse lymphoma model [13].