MYC and lymphoma: In consistent with the finding in del(11B3) lymphoma cells, multiple AA downstream metabolites produced from cyclooxygenase pathway, such as PGE2, PGD2 (Prostaglandin D2) and TXB2, were upregulated in Alox8-deficient lymphoma cells (shAlox8;Myc), compared with control lymphoma cells (shTrp53;Myc) (Fig. 1E).