In the present study, we found that RBM3 is associated with m6A regulation in PCa, and that high expression of RBM3 reduces catenin beta 1 (CTNNB1) mRNA stability by upregulating the m6A modification in the 3’UTR of CTNNB1, resulting in decreased protein levels of β-catenin, downregulation of Wnt signaling, and greatly attenuated stemness remodeling of PCa cells by osteoblasts. This evidence concerns the gene RBM3 and posterior cortical atrophy.