As it has been widely accepted that the bone microenvironment endows tumor cells with the capacity for stemness remodeling and secondary metastasis [4], it is reasonable to speculate that the loss of RBM3 expression, which likely favors the activation of Wnt/β-catenin signaling, may play a role in stemness remodeling in bone metastases of PCa. Here, RBM3 is linked to neoplasm.