Firstly, it was found that the mRNA abundance of CTNNB1 in PCa cells was significantly increased after co-culture with osteoblast cells, accompanied by extranuclear aggregation of CTNNB1 mRNA (Fig. 5a); in contrast, the m6A level on the mRNA of CTNNB1 at Site 1 did not change in this process (Fig. 5b). The gene discussed is CTNNB1; the disease is posterior cortical atrophy.