To test whether METTL3 was involved in this process, protein expression of METTL3 in PCa cells was first examined, which showed that METTL3 protein was expressed in all three PCa cell lines, although overexpression of RBM3 had little effect on METTL3 expression (Fig. 4c). The gene discussed is METTL3; the disease is posterior cortical atrophy.