Nonetheless, these findings indicate that TCR-mediated regulation of TGFβ-TβRI signaling is a crucial criterion in determining T cell quiescence and activation (Figure 1), which should have important implications for our understanding of immune tolerance and immune responses, as well as the development and pathogenesis of autoimmunity, cancer, and infectious diseases (Supplementary Text 2). This evidence concerns the gene TGFB1 and cancer.