Our previous study discovered a link between VDAC1 and invasion and metastasis of breast cancer cell proliferation, but VDAC1 in the molecular regulation mechanism of breast cancer is unclear, so the VDAC1 in the incidence of breast cancer, development of molecular mechanism, and study the related regulation can help to find new breast cancer treatment targets, and promote the development of precision medical treatment of breast cancer. This evidence concerns the gene VDAC1 and breast cancer.