The aim of ourstudy was to explore self-testing of endogenous LH release using a LH urine test12-hours after triggering as a method to predict a suboptimal response togonadotropin-releasing hormone agonist trigger in oocyte donation cycles defined asthe retrieval of zero oocytes (empty follicle syndrome) after an uneventful ovarianpuncture for egg-collection. The gene discussed is PLOD1; the disease is Empty ovarian follicle.