Tyrosine kinase Src is the major activator in the focal adhesion pathway (Guo and Giancotti, 2004; Seguin et al., 2015), and Src activity has been shown to be upregulated in castration-resistant PC samples and involved in androgen-independent growth (Varkaris et al., 2014; Tatarov et al., 2009). This evidence concerns the gene SRC and pachyonychia congenita.