Furthermore, based on molecularmodeling studies, two different strategies were applied to enhancecellular potency by implanting solubilizing groups, such as N-methyl piperazine in phenyl ring A and N,N,N′-trimethylethyl aminogroup in phenyl ring B to obtain various EGFR mutant-selective inhibitors(35, 38, 39, 40 and 41, 49, 50, 51, 52, 53, 55, 56, 57, and 58) that selectively inhibitedthe proliferation of H1975 over A431 NSCLC cells. This evidence concerns the gene EGFR and non-small cell lung carcinoma.