Consistent with increased hepatic steatosis, peroxisome proliferator–activated receptor γ (PPARG) expression, a driver of hepatic steatosis (37, 38), was induced 1.6-fold in Adipo-KO livers (Figure 3F), while other hepatic lipogenic genes, such as adipocyte protein 2 (AP2), sterol regulatory element binding protein-1a/1c (SREBP1A, SREBP1C), acetyl-CoA carboxylase 1 (ACC1), stearoyl-CoA desaturase 1 (SCD1), and fatty acid synthase (FAS), remained unchanged (Supplemental Figure 3A). This evidence concerns the gene ACACA and fatty liver disease.