PIEZO1 and metabolic dysfunction-associated steatotic liver disease: Indeed, a number of mechanoresponsive and mechanosensitive ion channels expressed in adipocytes, including transient receptor potential vanilloid type 4 (TRPV4) and mechanosensitive ion channel Piezo1, have been shown to regulate adipogenesis, adipocyte expansion, and thermogenesis in vitro and in vivo and can influence NAFLD (25–27).